Gregory L. Damhorst, MD, PhD

G. L. Damhorst*, J. Lin*, J. K. Frediani*, J. A. Sullivan, A. Westbrook, K. McLendon, et al. Comparison of RT-PCR and antigen test sensitivity across nasopharyngeal, nares, and oropharyngeal swab, and saliva sample types during the SARS-CoV-2 omicron variant. Heliyon 2024 Vol. 10 Issue 6. DOI: 10.1016/j.heliyon.2024.e27188.

Damhorst GL, McLendon K, Morales E, Solis ZM, Fitts E, Bowers HB, Sabino C, Sullivan J, Greenleaf M, Roback JD, Colasanti JA, Sheth AN, Titanji BK, Martin GS, Bassit L, Lam WA, Rao A. Performance of the Xpert™ Mpox PCR assay with oropharyngeal, anorectal, and cutaneous lesion swab specimens. J Clin Virol. 2024 Apr;171:105659. doi: 10.1016/j.jcv.2024.105659. Epub 2024 Feb 23. PMID: 38430669. 

Damhorst GL*, Fujita AW*, Fitts E, Szabo B, Bowers HB, Sabino C, Ahmed A, Wang E, Piantadosi A, McLendon K, Sullivan J, Greenleaf M, McCaslin D, Palmore M, Anderson AM, Aldred B, Gunthel C, Martin GS, Colasanti JA, Lam WA, Bassit L, Rao A, Sheth AN, Titanji BK. Multisite mpox infection and viral dynamics among persons with HIV in metro-Atlanta. J Infect Dis. 2023 Nov 29:jiad530. doi: 10.1093/infdis/jiad530. PMID: 38019187.

Cheedarla N, Verkerke HP, Potlapalli S, McLendon KB, Patel A, Frank F, O'Sick WH, Cheedarla S, Baugh TJ, Damhorst GL, Wu H, Graciaa D, Hudaib F, Alter DN, Bryksin J, Ortlund EA, Guarner J, Auld S, Shah S, Lam W, Mattoon D, Johnson JM, Wilson DH, Dhodapkar MV, Stowell SR, Neish AS, Roback JD. Rapid, high throughput, automated detection of SARS-CoV-2 neutralizing antibodies against Wuhan-WT, delta and omicron BA1, BA2 spike trimers. iScience. 2023 Oct 18;26(11):108256. doi: 10.1016/j.isci.2023.108256. PMID: 37965140; PMCID: PMC10641509. 

Lancelot M, Fibben K, Sullivan J, O'Sick W, McLendon K, Wu H, Rao A, Bassit LC, Greenleaf M, Miller P, Krull W, Tyburski E, Roback JD, Lam WA*, Damhorst GL*. Effect of swab pooling on the Accula point-of-care RT-PCR for SARS-CoV-2 detection. Front Microbiol. 2023 Aug 7;14:1219214. doi: 10.3389/fmicb.2023.1219214. PMID: 37608952; PMCID: PMC10440424. 

Mermin-Bunnell K, Zhu Y, Hornback A, Damhorst G, Walker T, Robichaux C, Mathew L, Jaquemet N, Peters K, Johnson TM 2nd, Wang MD, Anderson B. Use of Natural Language Processing of Patient-Initiated Electronic Health Record Messages to Identify Patients With COVID-19 Infection. JAMA Netw Open. 2023 Jul 3;6(7):e2322299. doi: 10.1001/jamanetworkopen.2023.22299. PMID: 37418261; PMCID: PMC10329205. 

Damhorst GL, Schoof N, Nguyen PV, Verkerke H, Wilber E, McLendon K, O'Sick W, Baugh T, Cheedarla S, Cheedarla N, Stittleburg V, Fitts EC, Neja MA, Babiker A, Piantadosi A, Roback JD, Waggoner JJ, Mavigner M, Lam WA. Investigation of blood plasma viral nucleocapsid antigen as a marker of active SARS-CoV-2 Omicron variant infection, Open Forum Infect Dis. 2023 May 2;10(5):ofad226. doi: 10.1093/ofid/ofad226. PMID: 37213426; PMCID: PMC10199120.

Greenleaf MN, Nehl E, Damhorst GL, Lam WA. Pivot, persevere, or perish: how Ellume Health overcame development and regulatory obstacles to become the first authorized over-the-counter COVID-19 test in the United States. Lab Chip. 2023 May 2. doi: 10.1039/d3lc00118k. Epub ahead of print. PMID: 37129954. 

Damhorst GL, Verkerke HP, Harrington KRV, McLendon K, Lu A, Perez MA, Hussaini L, Anderson EJ, Stowell SR, Roback JD, Lam WA, Rostad CA. SARS-CoV-2 Antigenemia is Associated With Pneumonia in Children But Lacks Sensitivity to Diagnose Acute Infection. Pediatr Infect Dis J. 2023 Feb 1;42(2):130-135. doi: 10.1097/INF.0000000000003779. Epub 2022 Jan 11. PMID: 36638399; PMCID: PMC9838602. 

Wilber E, Piantadosi A, Babiker A, McLendon K, O'Sick W, Fitts E, Webster AS, Verkerke H, Kim JS, Phadke VK, Rouphael N, Titanji BK, Blake WT, Howard-Anderson J, Roback JD, Lam WA*, Damhorst GL*. Nucleocapsid Antigenemia in Patients Receiving Anti-CD20 Therapy With Protracted COVID-19. Open Forum Infect Dis. 2022 Aug 17;9(8):ofac419. doi: 10.1093/ofid/ofac419. PMID: 36043176; PMCID: PMC9416058. 

Verkerke HP*, Damhorst GL*, Graciaa DS, McLendon K, O'Sick W, Robichaux C, Cheedarla N, Potlapalli S, Wu SC, Harrington KRV, Webster A, Kraft C, Rostad CA, Waggoner JJ, Gandhi NR, Guarner J, Auld SC, Neish A, Roback JD, Lam WA, Shah NS, Stowell SR. Nucleocapsid Antigenemia Is a Marker of Acute SARS-CoV-2 Infection. J Infect Dis. 2022 Jul 25:jiac225. doi: 10.1093/infdis/jiac225. Epub ahead of print. PMID: 35877413. 

Farmer S, Razin V, Peagler AF, Strickler S, Fain WB, Damhorst GL, Kempker RR, Pollock NR, Brand O, Seitter B, Heilman SS, Nehl EJ, Levy JM, Gottfried DS, Martin GS, Greenleaf M, Ku DN, Waggoner JJ, Iffrig E, Mannino R, Wang YF, Ortlund E, Sullivan J, Rebolledo PA, Clavería V, Roback JD, Benoit M, Stone C, Esper A, Frank F, Lam WA. Don't Forget About Human Factors: Lessons Learned from COVID-19 Point-of-Care Testing. Cell Rep Methods. 2022 May 3:100222. doi: 10.1016/j.crmeth.2022.100222. Epub ahead of print. PMID: 35527805; PMCID: PMC9061138. 

Greenleaf MN, Damhorst GL, Ku DN, Nehl EJ, Tyburski EA, Brand O, Martin GS, Lam WA. Designing for simplicity: lessons from Mesa Biotech for microfluidic entrepreneurs and early-stage companies. Lab Chip. 2022 Apr 12;22(8):1469-1473. doi: 10.1039/d2lc00081d. PMID: 35342919; PMCID: PMC9012986. 

Damhorst GL, Watts A, Hernandez-Romieu A, Mel N, Palmore M, Ali IKM, Neill SG, Kalapila A, Cope JR. Acanthamoeba castellanii encephalitis in a patient with AIDS: a case report and literature review. Lancet Infect Dis. 2022 Feb;22(2):e59-e65. doi: 10.1016/S1473-3099(20)30933-6. Epub 2021 Aug 27. PMID: 34461057. 

Damhorst GL, Broder KJ, Overton EC, Rara R, Busch LM, Burd EM, Webster AS, Kraft CS, Babiker A. Clinical Utilization of DiaSorin Molecular Polymerase Chain Reaction in Pneumocystis Pneumonia. Open Forum Infect Dis. 2022 Jan 10;9(1):ofab634. doi: 10.1093/ofid/ofab634. PMID: 35036467; PMCID: PMC8754379. 

Taneja I*, Damhorst GL*, Lopez-Espina C, Zhao SD, Zhu R, Khan S, White K, Kumar J, Vincent A, Yeh L, Majdizadeh S, Weir W, Isbell S, Skinner J, Devanand M, Azharuddin S, Meenakshisundaram R, Upadhyay R, Syed A, Bauman T, Devito J, Heinzmann C, Podolej G, Shen L, Timilsina SS, Quinlan L, Manafirasi S, Valera E, Reddy B Jr, Bashir R. Diagnostic and prognostic capabilities of a biomarker and EMR-based machine learning algorithm for sepsis. Clin Transl Sci. 2021 Jul;14(4):1578-1589. doi: 10.1111/cts.13030. Epub 2021 May 2. PMID: 33786999; PMCID: PMC8301583. 

Damhorst GL, Adelman MW, Woodworth MH, Kraft CS. Current Capabilities of Gut Microbiome-Based Diagnostics and the Promise of Clinical Application. J Infect Dis. 2021 Jun 16;223(12 Suppl 2):S270-S275. doi: 10.1093/infdis/jiaa689. PMID: 33330938; PMCID: PMC8206793. 

Damhorst GL, Tyburski EA, Brand O, Martin GS, Lam WA. Diagnosis of acute serious illness: the role of point-of-care technologies. Curr Opin Biomed Eng. 2019 Sep;11:22-34. doi: 10.1016/j.cobme.2019.08.012. Epub 2019 Sep 16. PMID: 34079919; PMCID: PMC8168915.

Ghonge T , Ceylan Koydemir H , Valera E , Berger J , Garcia C , Nawar N , Tiao J , Damhorst GL , Ganguli A , Hassan U , Ozcan A , Bashir R . Smartphone-imaged microfluidic biochip for measuring CD64 expression from whole blood. Analyst. 2019 Jul 7;144(13):3925-3935. doi: 10.1039/c9an00532c. Epub 2019 May 16. PMID: 31094395. 

Ganguli A, Ornob A, Spegazzini N, Liu Y, Damhorst G, Ghonge T, Thornton B, Konopka CJ, Dobrucki W, Clare SE, Bhargava R, Smith AM, Kosari F, Bashir R. Pixelated spatial gene expression analysis from tissue. Nat Commun. 2018 Jan 15;9(1):202. doi: 10.1038/s41467-017-02623-9. PMID: 29335461; PMCID: PMC5768672.

Ghonge T, Ganguli A, Valera E, Saadah M, Damhorst GL, Berger J, Pagan Diaz G, Hassan U, Chheda M, Haidry Z, Liu S, Hwu C, Bashir R. A microfluidic technique to estimate antigen expression on particles. APL Bioeng. 2017 Oct 9;1(1):016103. doi: 10.1063/1.4989380. PMID: 31069283; PMCID: PMC6481692.  

Taneja I, Reddy B, Damhorst G, Dave Zhao S, Hassan U, Price Z, Jensen T, Ghonge T, Patel M, Wachspress S, Winter J, Rappleye M, Smith G, Healey R, Ajmal M, Khan M, Patel J, Rawal H, Sarwar R, Soni S, Anwaruddin S, Davis B, Kumar J, White K, Bashir R, Zhu R. Combining Biomarkers with EMR Data to Identify Patients in Different Phases of Sepsis. Sci Rep. 2017 Sep 7;7(1):10800. doi: 10.1038/s41598-017-09766-1. Erratum in: Sci Rep. 2019 Nov 19;9(1):17419. PMID: 28883645; PMCID: PMC5589821. 

Ganguli A, Ornob A, Yu H, Damhorst GL, Chen W, Sun F, Bhuiya A, Cunningham BT, Bashir R. Hands-free smartphone-based diagnostics for simultaneous detection of Zika, Chikungunya, and Dengue at point-of-care. Biomed Microdevices. 2017 Aug 22;19(4):73. doi: 10.1007/s10544-017-0209-9. PMID: 28831630.

Damhorst GL, Kooiman JM, Bashir R. HIV-1 IIIB capture from whole blood on magnetic microparticles. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:5785-5788. doi: 10.1109/EMBC.2016.7592042. PMID: 28269569. 

Hassan U, Watkins NN, Reddy B Jr, Damhorst G, Bashir R. Microfluidic differential immunocapture biochip for specific leukocyte counting. Nat Protoc. 2016 Apr;11(4):714-26. doi: 10.1038/nprot.2016.038. Epub 2016 Mar 10. PMID: 26963632; PMCID: PMC4893332. 

Hassan U, Reddy B Jr, Damhorst G, Sonoiki O, Ghonge T, Yang C, Bashir R. A microfluidic biochip for complete blood cell counts at the point-of-care. Technology (Singap World Sci). 2015 Dec;3(4):201-213. doi: 10.1142/S2339547815500090. Epub 2015 Dec 11. PMID: 26909365; PMCID: PMC4761450. 

Damhorst GL, Duarte-Guevara C, Chen W, Ghonge T, Cunningham BT, Bashir R. Smartphone-Imaged HIV-1 Reverse-Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) on a Chip from Whole Blood. Engineering (Beijing). 2015 Sep;1(3):324-335. doi: 10.15302/J-ENG-2015072. Epub 2015 Oct 16. PMID: 26705482; PMCID: PMC4687746. 

Khatib O, Wood JD, McLeod AS, Goldflam MD, Wagner M, Damhorst GL, Koepke JC, Doidge GP, Rangarajan A, Bashir R, Pop E, Lyding JW, Thiemens MH, Keilmann F, Basov DN. Graphene-Based Platform for Infrared Near-Field Nanospectroscopy of Water and Biological Materials in an Aqueous Environment. ACS Nano. 2015 Aug 25;9(8):7968-75. doi: 10.1021/acsnano.5b01184. Epub 2015 Aug 5. PMID: 26223158.

Damhorst GL, Murtagh M, Rodriguez WR, Bashir R. Microfluidics and Nanotechnology for Detection of Global Infectious Diseases. Proceedings of the IEEE. 2015 March; 103(2):150. doi: 10.1109/JPROC.2014.2385078.

Watkins NN, Hassan U, Damhorst G, Ni H, Vaid A, Rodriguez W, Bashir R. Microfluidic CD4+ and CD8+ T lymphocyte counters for point-of-care HIV diagnostics using whole blood. Sci Transl Med. 2013 Dec 4;5(214):214ra170. doi: 10.1126/scitranslmed.3006870. PMID: 24307694. 

Damhorst GL, Smith CE, Salm EM, Sobieraj MM, Ni H, Kong H, Bashir R. A liposome-based ion release impedance sensor for biological detection. Biomed Microdevices. 2013 Oct;15(5):895-905. doi: 10.1007/s10544-013-9778-4. PMID: 23793417; PMCID: PMC4079459. 

Damhorst GL, Watkins NN, Bashir R. Micro- and nanotechnology for HIV/AIDS diagnostics in resource-limited settings. IEEE Trans Biomed Eng. 2013 Mar;60(3):715-26. doi: 10.1109/TBME.2013.2244894. PMID: 23512111.